Susceptibility to penicillin derivatives among third-generation cephalosporin-resistant Enterobacteriaceae recovered on hospital admission

Diagn Microbiol Infect Dis. 2017 Jan;87(1):71-73. doi: 10.1016/j.diagmicrobio.2016.09.012. Epub 2016 Sep 23.

Abstract

As part of the multicenter Antibiotic Therapy Optimisation Study-the largest study on the prevalence of third-generation cephalosporin-resistant Enterobacteriaceae carriage upon hospital admission-minimum inhibitory concentration values were generated for ampicillin/sulbactam, amoxicillin/clavulanic acid, piperacillin/tazobactam, mecillinam, mecillinam/clavulanic acid, and temocillin against third-generation cephalosporin-resistant Escherichia coli, Klebsiella species and Enterobacter species.

Keywords: AmpC; Extended-spectrum β-lactamase; β-Lactamase inhibitor.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Cephalosporins / pharmacology
  • Diagnostic Tests, Routine
  • Enterobacteriaceae / drug effects*
  • Enterobacteriaceae / isolation & purification
  • Enterobacteriaceae Infections / microbiology*
  • Humans
  • Microbial Sensitivity Tests
  • Penicillins / pharmacology*
  • beta-Lactam Resistance*
  • beta-Lactamase Inhibitors / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Cephalosporins
  • Penicillins
  • beta-Lactamase Inhibitors