HLA-A, -B and -DRB1 genotyping and haplotype frequencies of 3892 cord blood units in the Hong Kong Chinese Cord Blood Registry

Hum Immunol. 2016 Dec;77(12):1109-1110. doi: 10.1016/j.humimm.2016.10.006. Epub 2016 Oct 18.

Abstract

HLA-A, -B and -DRB1 gene and haplotype frequencies have been calculated from 3892 southern Chinese unrelated cord blood units in a Hong Kong Cord Blood Registry. This is the first large-scale paper to report the distribution of A-B-DRB1 alleles in Hong Kong Chinese Cord Blood Units. This information is important for estimating the optimal and economically cost-effective donor size and likelihood of obtaining appropriately matched cord blood units for Chinese patients awaiting haematopoietic stem cell transplantation. The data are available in the Allele Frequencies Net Database under the population name ''Hong Kong Chinese Cord Blood Registry'' and the identifier (AFND003358).

Keywords: Chinese; Cord blood; Gene frequency; HLA; Haplotype frequency; Hong Kong; Registry.

MeSH terms

  • Asian People
  • Blood Banks
  • Fetal Blood / transplantation
  • Gene Frequency
  • Genetics, Population*
  • Genotype
  • HLA-A Antigens / genetics*
  • HLA-B Antigens / genetics*
  • HLA-DRB1 Chains / genetics*
  • Haplotypes
  • Hematopoietic Stem Cell Transplantation
  • Histocompatibility Testing
  • Hong Kong
  • Humans
  • Registries

Substances

  • HLA-A Antigens
  • HLA-B Antigens
  • HLA-DRB1 Chains