Abstract
The phytochemical study of Stereocaulon montagneanum harvested in Sumatra (Indonesia) led to the isolation of 11 known compounds including two metabolites not previously described in the genus Stereocaulon, peristictic acid (8) and menegazziaic acid (10). The complete 1H and 13C NMR spectral assignments of stictic acid derivatives are reported with some revisions. Five depsidones belonging to the stictic acid chemosyndrome were superoxide anion scavengers as potent as ascorbic acid and with no toxicity on two human cell lines.
MeSH terms
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Animals
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Antioxidants / chemistry
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Antioxidants / isolation & purification
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Antioxidants / pharmacology*
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Cell Line
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Drug Evaluation, Preclinical
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Free Radical Scavengers / chemistry
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Free Radical Scavengers / isolation & purification
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Free Radical Scavengers / pharmacology*
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Heterocyclic Compounds, 4 or More Rings / chemistry
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Heterocyclic Compounds, 4 or More Rings / isolation & purification
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Heterocyclic Compounds, 4 or More Rings / pharmacology*
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Humans
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Indonesia
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Keratinocytes / drug effects
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Keratinocytes / radiation effects
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Lichens / chemistry*
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Melanoma, Experimental
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Mice
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Oxepins / chemistry
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Oxepins / isolation & purification
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Oxepins / pharmacology*
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Radiation-Protective Agents / chemistry
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Radiation-Protective Agents / isolation & purification
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Radiation-Protective Agents / pharmacology*
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Solvents
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Superoxides / metabolism*
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Ultraviolet Rays
Substances
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Antioxidants
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Free Radical Scavengers
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Heterocyclic Compounds, 4 or More Rings
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Oxepins
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Radiation-Protective Agents
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Solvents
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stictic acid
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Superoxides