Abstract
Transforming growth factor (TGF)-β cytokines signal via a complex network of pathways to regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. A high percentage of colorectal tumors contain mutations that disrupt TGF-β family member signaling. We review how TGF-β family member signaling is altered during development of colorectal cancer, models of study, interaction of pathways, and potential therapeutic strategies.
Keywords:
Activin; Colon Cancer; Transforming Growth Factor β.
Copyright © 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.
Publication types
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Review
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Activins / metabolism
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Animals
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Bone Morphogenetic Proteins / metabolism
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Colorectal Neoplasms / genetics*
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Colorectal Neoplasms / immunology
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Colorectal Neoplasms / metabolism*
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Germ-Line Mutation
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Homeostasis
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Humans
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Mice
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Mice, Knockout
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Receptors, Transforming Growth Factor beta / genetics*
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Receptors, Transforming Growth Factor beta / immunology
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Signal Transduction*
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Smad Proteins / genetics*
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Smad Proteins / metabolism
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Transforming Growth Factor beta / genetics*
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Transforming Growth Factor beta / metabolism*
Substances
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Bone Morphogenetic Proteins
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Receptors, Transforming Growth Factor beta
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Smad Proteins
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Transforming Growth Factor beta
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Activins