Thin layer chromatographic detection of kryptofix 2.2.2 in the routine synthesis of [18F]2-fluoro-2-deoxy-D-glucose

Int J Rad Appl Instrum B. 1989;16(4):385-7. doi: 10.1016/0883-2897(89)90105-0.

Abstract

A simple procedure for the detection of 4,7,13,16,21,24-hexaoxa-1,10-diazabicyclo (8.8.8) hexacosane (Kryptofix 2.2.2) in the final solution of [18F]FDG prepared by the aminopolyether supported nucleophilic substitution of 1,3,4,6-tetra-O-acetyl 2-O-trifluoromethanesulfonyl-beta-D-mannopyranose (Hamacher et al., 1986) has been developed. Presence of Kryptofix 2.2.2 in the routine production of [18F]FDG was detected using methanol/ammonium hydroxide (9:1) solvent system. A method to remove Kryptofix from [18F]FDG solution has been suggested.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bridged Bicyclo Compounds / analysis*
  • Bridged Bicyclo Compounds, Heterocyclic*
  • Bridged-Ring Compounds / analysis*
  • Chelating Agents / analysis*
  • Chromatography, Thin Layer*
  • Deoxy Sugars / chemical synthesis*
  • Deoxyglucose / analogs & derivatives
  • Deoxyglucose / chemical synthesis*
  • Fluorine Radioisotopes*
  • Fluorodeoxyglucose F18
  • Humans

Substances

  • Bridged Bicyclo Compounds
  • Bridged Bicyclo Compounds, Heterocyclic
  • Bridged-Ring Compounds
  • Chelating Agents
  • Deoxy Sugars
  • Fluorine Radioisotopes
  • Fluorodeoxyglucose F18
  • cryptating agent 222
  • Deoxyglucose