Palladium-Catalyzed Direct Cross-Coupling of Carboranyllithium with (Hetero)Aryl Halides

Ju-You Lu; Hong Wan; Jianwei Zhang; Zhixuan Wang; Yang Li; Yongmei Du; Chunying Li; Zhao-Tie Liu; Zhong-Wen Liu; Jian Lu

doi:10.1002/chem.201603967

Palladium-Catalyzed Direct Cross-Coupling of Carboranyllithium with (Hetero)Aryl Halides

Chemistry. 2016 Dec 5;22(49):17542-17546. doi: 10.1002/chem.201603967. Epub 2016 Oct 26.

Authors

Ju-You Lu¹, Hong Wan¹, Jianwei Zhang¹, Zhixuan Wang¹, Yang Li¹, Yongmei Du¹, Chunying Li¹, Zhao-Tie Liu², Zhong-Wen Liu², Jian Lu¹

Affiliations

¹ State Key Laboratory of Fluorine & Nitrogen Chemicals, Xi'an Modern Chemistry Research Institute, Xi'an, 710065, P. R. China.
² Key Laboratory of Applied Surface and Colloid Chemistry (Ministry of Education), School of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an, 710119, P. R. China.

PMID: 27782302
DOI: 10.1002/chem.201603967

Abstract

A palladium-catalyzed direct C-arylation reaction of readily available cage carboranyllithium reagents with aryl halides has been developed for the first time. This method is applicable to a wide range of aryl halide substrates including aryl iodides, aryl bromides, and heteroaromatic halides.

Keywords: C(cage)−C(sp2) formation; carboranyllithium; cross-coupling; direct C-arylation; palladium.