Abstract
The peculiarities in expression of transport proteins and the proteins implicated in the control of glycolysis by the cellular components of neurovascular units were examined in animals of different age under normal conditions and after modeled perinatal stress or hypoxic brain injury. In both cases, the specialties in expression of transport proteins in ontogenesis were revealed. The perinatal hypoxic brain injury resulted in up-regulation of MCT1, MCT4, and GLUT4 expression in endotheliocytes of hippocampal microvessels accompanied by transient elevation of HIF-1α and GSK3 expression.
Keywords:
hippocampus; hypoxia; neurovascular unit; stress; transport proteins.
MeSH terms
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Age Factors
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Animals
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Animals, Newborn
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Anxiety, Separation / complications
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Anxiety, Separation / genetics*
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Anxiety, Separation / metabolism
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Anxiety, Separation / pathology
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Astrocytes / metabolism
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Astrocytes / pathology
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Blood-Brain Barrier / metabolism
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Blood-Brain Barrier / pathology
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Endothelial Cells / metabolism
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Endothelial Cells / pathology
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Female
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Gene Expression Regulation
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Glucose Transporter Type 4 / genetics*
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Glucose Transporter Type 4 / metabolism
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Glycogen Synthase Kinase 3 / genetics*
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Glycogen Synthase Kinase 3 / metabolism
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Hippocampus / blood supply
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Hippocampus / metabolism
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Hippocampus / pathology
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Humans
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Hypoxia / complications
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Hypoxia / genetics*
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Hypoxia / metabolism
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Hypoxia / pathology
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Hypoxia-Inducible Factor 1, alpha Subunit / genetics*
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Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
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Male
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Microvessels / metabolism
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Microvessels / pathology
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Neurons / metabolism
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Neurons / pathology
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Neurovascular Coupling
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Rats
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Rats, Wistar
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Stress, Psychological / complications
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Stress, Psychological / genetics*
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Stress, Psychological / metabolism
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Stress, Psychological / pathology
Substances
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Glucose Transporter Type 4
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Hif1a protein, rat
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Hypoxia-Inducible Factor 1, alpha Subunit
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Slc2a4 protein, rat
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Glycogen Synthase Kinase 3