Example of the drug interaction between ciclosporin and orlistat, resulting in relapse of Evan's syndrome

BMJ Case Rep. 2016 Oct 28:2016:bcr2016217246. doi: 10.1136/bcr-2016-217246.

Abstract

A man aged 35 years with a history of Evan's syndrome presented to the clinic with jaundice and shortness of breath, with further testing indicating a relapse of his previously well-controlled condition, for which he was taking ciclosporin. This followed shortly after he had started taking orlistat to prevent weight gain from a course of steroids, and once the orlistat was stopped, his platelets began to rise. The patient required 4 months of steroid treatment before his platelet levels finally stabilised and he could be put back on his regular medicine regime.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anemia, Hemolytic, Autoimmune / chemically induced*
  • Anemia, Hemolytic, Autoimmune / drug therapy
  • Anti-Obesity Agents / adverse effects*
  • Cyclosporine / adverse effects*
  • Drug Interactions
  • Humans
  • Immunosuppressive Agents / adverse effects*
  • Lactones / adverse effects*
  • Male
  • Orlistat
  • Recurrence
  • Thrombocytopenia / chemically induced*
  • Thrombocytopenia / drug therapy

Substances

  • Anti-Obesity Agents
  • Immunosuppressive Agents
  • Lactones
  • Cyclosporine
  • Orlistat

Supplementary concepts

  • Evans Syndrome