Perioperative outcomes and survival in elderly patients undergoing laparoscopic distal pancreatectomy

J Hepatobiliary Pancreat Sci. 2017 Jan;24(1):42-48. doi: 10.1002/jhbp.409.

Abstract

Background: The outcomes following laparoscopic distal pancreatectomy (LDP) in elderly patients have not been widely reported to date. This study aimed to analyze perioperative and oncologic outcomes in patients aged ≥70 years (elderly group) and compare with those <70 years (non-elderly group).

Methods: From April 1997 to September 2015, 402 consecutive patients with lesions in the body and tail of the pancreas underwent LDP at Rikshospitalet, Oslo University Hospital.

Results: Of these, 118 (29.4%) were elderly, whereas 284 (70.6%) were non-elderly. Despite higher rate of comorbidities and American Society of Anesthesiologists score (P = 0.001 and 0.001, respectively), elderly patients had lower postoperative morbidity, pancreatic fistula (PF) and readmission rates, compared with non-elderly (P = 0.032, 0.001 and 0.025, respectively). Spleen-preserving LDP (SPLDP) resulted in similar postoperative outcomes in the two groups. Elderly patients with pancreatic ductal adenocarcinoma (PDAC) were comparable to non-elderly in terms of median and 3-year survival (20.2 vs. 19 months (P = 0.94, log-rank) and 26.7% vs. 34.3%, respectively).

Conclusions: Both LDP and SPLDP are safe in patients aged ≥70 years, providing outcomes similar to those in younger group. Elderly patients with PDAC can benefit from LDP, since age itself is not associated with decreased survival after surgery.

Keywords: Adenocarcinoma; Elderly; Laparoscopy; Pancreatectomy; Survival.

Publication types

  • Comparative Study

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Carcinoma, Pancreatic Ductal / mortality*
  • Carcinoma, Pancreatic Ductal / pathology
  • Carcinoma, Pancreatic Ductal / surgery*
  • Cause of Death*
  • Cohort Studies
  • Disease-Free Survival
  • Geriatric Assessment
  • Hospitals, University
  • Humans
  • Intraoperative Complications / mortality
  • Intraoperative Complications / physiopathology
  • Kaplan-Meier Estimate
  • Laparoscopy / adverse effects
  • Laparoscopy / methods*
  • Middle Aged
  • Norway
  • Pancreatectomy / adverse effects
  • Pancreatectomy / methods*
  • Pancreatic Neoplasms / mortality*
  • Pancreatic Neoplasms / pathology
  • Pancreatic Neoplasms / surgery*
  • Perioperative Care / methods
  • Postoperative Complications / mortality
  • Postoperative Complications / physiopathology
  • Prognosis
  • Retrospective Studies
  • Risk Assessment
  • Statistics, Nonparametric
  • Survival Analysis