A Novel erm(44) Gene Variant from a Human Staphylococcus saprophyticus Isolate Confers Resistance to Macrolides and Lincosamides but Not Streptogramins

Antimicrob Agents Chemother. 2016 Dec 27;61(1):e01655-16. doi: 10.1128/AAC.01655-16. Print 2017 Jan.

Abstract

A novel erm(44) gene variant, erm(44)v, has been identified by whole-genome sequencing in a Staphylococcus saprophyticus isolate from the skin of a healthy person. It has the particularity to confer resistance to macrolides and lincosamides but not to streptogramin B when expressed in S. aureus The erm(44)v gene resides on a 19,400-bp genomic island which contains phage-associated proteins and is integrated into the chromosome of S. saprophyticus.

Keywords: 23S RNA methylase; MLSB; Staphylococcus; antibiotic resistance; coagulase-negative staphylococci; macrolides-lincosamides-streptogramin B; phages.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Drug Resistance, Multiple, Bacterial / genetics
  • Genomic Islands / genetics
  • Humans
  • Lincosamides / pharmacology*
  • Macrolides / pharmacology*
  • Microbial Sensitivity Tests
  • Staphylococcus / drug effects
  • Staphylococcus / metabolism
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / genetics
  • Streptogramin B / pharmacology
  • Streptogramins / pharmacology*

Substances

  • Bacterial Proteins
  • Lincosamides
  • Macrolides
  • Streptogramins
  • Streptogramin B