Redox regulation of transient receptor potential channels in the endothelium

Microcirculation. 2017 Apr;24(3):10.1111/micc.12329. doi: 10.1111/micc.12329.

Abstract

ROS and RNS are important mediators of signaling pathways in the endothelium. Specific members of the TRP superfamily of cation channels act as important Ca2+ influx pathways in endothelial cells and are involved in endothelium-dependent vasodilation, regulation of barrier permeability, and angiogenesis. ROS and RNS can modulate the activity of certain TRP channels mainly by modifying specific cysteine residues or by stimulating the production of second messengers. In this review, we highlight the recent literature describing redox regulation of TRP channel activity in endothelial cells as well as the physiological importance of these pathways and implication for cardiovascular diseases.

Keywords: Ca2+ influx; TRP channels; endothelial cells; redox signaling.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Endothelium, Vascular / metabolism*
  • Humans
  • Oxidation-Reduction*
  • Reactive Nitrogen Species / metabolism
  • Reactive Oxygen Species / metabolism
  • Second Messenger Systems
  • Signal Transduction
  • Transient Receptor Potential Channels / metabolism*

Substances

  • Reactive Nitrogen Species
  • Reactive Oxygen Species
  • Transient Receptor Potential Channels