Chromatin Starts to Come Clean

Mol Cell. 2016 Nov 3;64(3):439-441. doi: 10.1016/j.molcel.2016.10.022.

Abstract

In an effort to identify a chromatin-associated pluripotent network, Rafiee et al., (2016) developed a powerful ChIP-MS technique and discovered a novel protein, TRIM24, enriched on OCT4-, SOX2-, and NANOG-associated chromatin, paving the way for future proteomic studies on chromatin.

Publication types

  • Comment

MeSH terms

  • Animals
  • Binding Sites
  • Cell Differentiation
  • Cellular Reprogramming
  • Chromatin / chemistry*
  • Chromatin / metabolism
  • Chromatin Immunoprecipitation / methods
  • Gene Expression Profiling
  • Gene Expression Regulation
  • Isotope Labeling
  • Mass Spectrometry / methods
  • Mice
  • Mouse Embryonic Stem Cells / cytology
  • Mouse Embryonic Stem Cells / metabolism*
  • Nanog Homeobox Protein / genetics*
  • Nanog Homeobox Protein / metabolism
  • Nuclear Proteins / genetics*
  • Nuclear Proteins / metabolism
  • Octamer Transcription Factor-3 / genetics*
  • Octamer Transcription Factor-3 / metabolism
  • Pluripotent Stem Cells / cytology
  • Pluripotent Stem Cells / metabolism*
  • Protein Binding
  • SOXB1 Transcription Factors / genetics*
  • SOXB1 Transcription Factors / metabolism
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism

Substances

  • Chromatin
  • Nanog Homeobox Protein
  • Nanog protein, mouse
  • Nuclear Proteins
  • Octamer Transcription Factor-3
  • Pou5f1 protein, mouse
  • SOXB1 Transcription Factors
  • Sox2 protein, mouse
  • Transcription Factors
  • transcriptional intermediary factor 1