Abstract
Despite great interest, two randomised controlled trials (RCTs) of cytoreductive nephrectomy in the tyrosine kinase inhibitor setting in metastatic renal cell carcinoma have either closed early (SURTIME) or are recruiting very slowly (CARMENA) after 7 yr. Challenges in RCT delivery in uro-oncologic surgery are many. Multiple steps are needed to ensure strong recruitment to trials addressing important urologic cancer questions. Feasibility/pilot studies are key stepping stones towards successful delivery of surgical RCTs.
Copyright © 2016 European Association of Urology. Published by Elsevier B.V. All rights reserved.
Publication types
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Editorial
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / adverse effects
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Antineoplastic Agents / therapeutic use*
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Carcinoma, Renal Cell / enzymology
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Carcinoma, Renal Cell / pathology
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Carcinoma, Renal Cell / therapy*
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Chemotherapy, Adjuvant
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Cytoreduction Surgical Procedures / adverse effects
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Cytoreduction Surgical Procedures / methods*
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Evidence-Based Medicine
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Humans
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Kidney Neoplasms / enzymology
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Kidney Neoplasms / pathology
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Kidney Neoplasms / therapy*
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Molecular Targeted Therapy
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Nephrectomy* / adverse effects
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Protein Kinase Inhibitors / adverse effects
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Protein Kinase Inhibitors / therapeutic use*
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Randomized Controlled Trials as Topic
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Treatment Outcome
Substances
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Antineoplastic Agents
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Protein Kinase Inhibitors