Management of Acute Kidney Injury in Pregnancy for the Obstetrician

Obstet Gynecol Clin North Am. 2016 Dec;43(4):747-765. doi: 10.1016/j.ogc.2016.07.007.

Abstract

Acute kidney injury (AKI) is a complex disorder that occurs in several clinical settings. During pregnancy, there are additional unique conditions that contribute to AKI. The clinical manifestations of AKI during pregnancy range from a minimal elevation in serum creatinine to renal failure requiring renal replacement therapy, similar to AKI in the general population. Recent epidemiologic studies in the general population show an increase in mortality associated with AKI, particularly when dialysis is required. The incidence of AKI in pregnancy remains a cause of significant morbidity and mortality.

Keywords: Acute kidney injury; Atypical hemolytic uremic syndrome; Hypertensive disorders of pregnancy; Preeclampsia; Pregnancy-related acute kidney injury; Thrombotic microangiopathy.

Publication types

  • Review

MeSH terms

  • Acute Kidney Injury* / diagnosis
  • Acute Kidney Injury* / etiology
  • Acute Kidney Injury* / physiopathology
  • Acute Kidney Injury* / therapy
  • Female
  • Humans
  • Incidence
  • Kidney Function Tests / methods
  • Pregnancy
  • Pregnancy Complications* / diagnosis
  • Pregnancy Complications* / etiology
  • Pregnancy Complications* / physiopathology
  • Pregnancy Complications* / therapy
  • Pregnancy Outcome
  • Renal Replacement Therapy / methods*
  • Risk Factors
  • Severity of Illness Index