Abstract
Our studies demonstrate that in the explanation of the protective effect of the calcium antagonist (S)-emopamil the possibility of beneficial metabolic causes (lower O2 consumption) must also be considered beside of blood flow increasing effects. It is suggested that (S)-emopamil may be a useful drug for the treatment of cerebro-ischemic disorders.
MeSH terms
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Animals
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Blood Pressure / drug effects
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Calcium Channel Blockers / pharmacology*
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Cats
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Cerebral Cortex / blood supply
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Cerebral Cortex / drug effects
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Cerebral Cortex / metabolism*
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Cerebrovascular Circulation* / drug effects*
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Female
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Hypotension / physiopathology*
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Male
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NAD / metabolism
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Oxidation-Reduction
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Reference Values
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Regional Blood Flow / drug effects
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Spectrometry, Fluorescence / methods
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Verapamil / analogs & derivatives*
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Verapamil / pharmacology
Substances
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Calcium Channel Blockers
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NAD
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Verapamil
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emopamil