PPAR-γ regulates pharmacological but not physiological or pathological osteoclast formation

Nat Med. 2016 Nov 8;22(11):1203-1205. doi: 10.1038/nm.4208.

Authors

Wei Zou¹, Nidhi Rohatgi¹, Timothy Hung-Po Chen², Joel Schilling³, Yousef Abu-Amer², Steven L Teitelbaum^{1

4}

Affiliations

¹ Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
² Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
³ Department of Medicine, Division of Cardiology, Washington University School of Medicine, St. Louis, Missouri, USA.
⁴ Department of Medicine, Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, Missouri, USA.

PMID: 27824823
PMCID: PMC5179330
DOI: 10.1038/nm.4208

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Diabetes Mellitus, Type 2 / drug therapy*
Flow Cytometry
Fractures, Bone / epidemiology*
Gene Knockdown Techniques
Humans
Macrophage Colony-Stimulating Factor / pharmacology
Mice
Osteoclasts / drug effects
Osteogenesis / drug effects*
PPAR gamma / agonists*
PPAR gamma / genetics
RANK Ligand / pharmacology
Thiazolidinediones / pharmacology*
Thiazolidinediones / therapeutic use

Substances

PPAR gamma
RANK Ligand
Thiazolidinediones
Macrophage Colony-Stimulating Factor

Grants and funding