Two new arylalkenyl α,β-unsaturated δ-lactones with cytotoxic activity from the leaves and twigs of Cryptocarya concinna

Nat Prod Res. 2017 Jun;31(12):1409-1413. doi: 10.1080/14786419.2016.1255886. Epub 2016 Nov 10.

Abstract

Tow new arylalkenyl α,β-unsaturated δ-lactones named cryptoconcatones K (1) and L (2) were obtained from the leaves and twigs of Cryptocarya concinna. Their structures were established on the basis of spectroscopic data (MS, 1D and 2D NMR). Compounds 1 and 2 showed cytotoxic activities with IC50 values of 4.5 and 3.9 μM against Huh7 cancer cell line, respectively.

Keywords: Cryptocarya concinna; Lauraceae; cytotoxic activities; α,β-unsaturated δ-lactones.

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Cell Line, Tumor
  • Cryptocarya / chemistry*
  • Humans
  • Lactones / chemistry
  • Lactones / isolation & purification*
  • Lactones / pharmacology
  • Magnetic Resonance Spectroscopy
  • Plant Leaves / chemistry

Substances

  • Antineoplastic Agents, Phytogenic
  • Lactones