Salmonella Gives MARCH(ing) Orders to MHC-II

Patrick A McLaughlin; Adrianus W M van der Velden

doi:10.1016/j.chom.2016.10.019

Salmonella Gives MARCH(ing) Orders to MHC-II

Cell Host Microbe. 2016 Nov 9;20(5):551-552. doi: 10.1016/j.chom.2016.10.019.

Authors

Patrick A McLaughlin¹, Adrianus W M van der Velden²

Affiliations

¹ Department of Molecular Genetics and Microbiology and Center for Infectious Diseases, 130 Life Sciences Building, Stony Brook University, Stony Brook, NY 11794-5120, USA.
² Department of Molecular Genetics and Microbiology and Center for Infectious Diseases, 130 Life Sciences Building, Stony Brook University, Stony Brook, NY 11794-5120, USA. Electronic address: [email protected].

PMID: 27832583
DOI: 10.1016/j.chom.2016.10.019

Abstract

How bacterial pathogens evade adaptive immunity is not well understood. In this issue of Cell Host & Microbe, Bayer-Santos et al. (2016) show that the Salmonella effector protein SteD mediates MARCH8-dependent ubiquitination of class II MHC molecules, thereby inhibiting antigen presentation and limiting T cell responses.

Publication types

Comment

MeSH terms

Antigen Presentation
Histocompatibility Antigens Class II / immunology*
Salmonella*
T-Lymphocytes / immunology
Ubiquitination

Substances

Histocompatibility Antigens Class II

Abstract

Publication types

MeSH terms

Substances

Grants and funding