Abstract
Salivary gland lysates of the sand fly Lutzomyia longipalpis contain a potent vasodilator that aids the fly to feed on the blood of its vertebrate hosts. Chromatographic analysis, antibody reactivity, and data obtained from bioassays of the salivary erythema-inducing factor indicate striking similarity with human calcitonin gene-related peptide. The erythema-inducing factor is, however, at least one order of magnitude more potent than calcitonin gene-related peptide.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Aorta / drug effects
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Aorta / physiology
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Calcitonin / pharmacology
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Calcitonin Gene-Related Peptide
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Chromatography, High Pressure Liquid
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Diptera
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Erythema
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Humans
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In Vitro Techniques
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Muscle, Smooth, Vascular / drug effects
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Muscle, Smooth, Vascular / physiology*
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Neuropeptides / pharmacology
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Rabbits
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Salivary Proteins and Peptides / isolation & purification*
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Salivary Proteins and Peptides / pharmacology
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Vasodilation
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Vasodilator Agents*
Substances
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Neuropeptides
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Salivary Proteins and Peptides
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Vasodilator Agents
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Calcitonin
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Calcitonin Gene-Related Peptide