Liquoral liquid biopsy in neoplastic meningitis enables molecular diagnosis and mutation tracking: a proof of concept

Neuro Oncol. 2017 Mar 1;19(3):451-453. doi: 10.1093/neuonc/now244.
No abstract available

Keywords: cell-free DNA; cerebrospinal fluid; liquid biopsy; metastasis; neoplastic meningitis; plasma.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / cerebrospinal fluid
  • Adenocarcinoma / diagnosis*
  • Adenocarcinoma / genetics
  • Cerebrospinal Fluid / cytology*
  • DNA Mutational Analysis / methods
  • ErbB Receptors / genetics
  • Female
  • Humans
  • Liquid Biopsy / methods*
  • Lung Neoplasms / cerebrospinal fluid
  • Lung Neoplasms / diagnosis*
  • Lung Neoplasms / genetics
  • Magnetic Resonance Imaging
  • Male
  • Meningeal Neoplasms / cerebrospinal fluid
  • Meningeal Neoplasms / diagnosis*
  • Meningeal Neoplasms / genetics
  • Meningitis / cerebrospinal fluid
  • Meningitis / diagnosis*
  • Meningitis / genetics
  • Middle Aged
  • Mutation*
  • Proto-Oncogene Proteins p21(ras) / genetics

Substances

  • KRAS protein, human
  • EGFR protein, human
  • ErbB Receptors
  • Proto-Oncogene Proteins p21(ras)