Mechanisms of Drug-Induced Hepatotoxicity

Clin Liver Dis. 2017 Feb;21(1):35-54. doi: 10.1016/j.cld.2016.08.002.

Abstract

Drug-induced hepatotoxicity (DIH) is a significant cause of acute liver failure and liver transplantation. Diagnosis is challenging due to the idiosyncratic nature, its presentation in the form of other liver disease, and the lack of a definite diagnostic criteria. Generation of reactive metabolites, oxidative stress, and mitochondrial dysfunction are common mechanisms involved in DIH. Certain risk factors associated with a drug and within an individual further predispose patients to DIH.

Keywords: Cholestasis; Hepatocellular; Hepatotoxicity; Mitochondria; Reactive metabolites.

Publication types

  • Review

MeSH terms

  • Chemical and Drug Induced Liver Injury / etiology*
  • Chemical and Drug Induced Liver Injury / physiopathology
  • Female
  • Humans
  • Liver / drug effects*
  • Liver Failure, Acute / chemically induced*
  • Liver Failure, Acute / mortality*
  • Liver Failure, Acute / physiopathology
  • Male
  • Needs Assessment
  • Oxidative Stress
  • Pharmaceutical Preparations / administration & dosage*
  • Prognosis
  • Risk Assessment
  • Survival Rate

Substances

  • Pharmaceutical Preparations