An oral airway frequently is utilized in maintaining a patent airway. However, a patient must be able to tolerate such an aid. This study suggests that propofol induction is superior to thiopental (Pentothol) induction in this regard, because it allows for prompt and earlier airway insertion. Propofol, a phenol derivative, is an ultra-short-acting intravenous and maintenance agent. It features a rapid onset, short duration of action and rapid distribution and elimination, allowing patients to make a quick recovery. One-hundred fifty-two patients were studied in comparing propofol induction with pentothol induction. Oral airway insertion was attempted in all patients, and tolerance was evaluated. There was a statistically significant difference between thiopental induction and propofol induction in the non-smoking groups, showing that propofol induction was superior. In the smoking groups, no statistically significant differences were noted. Manifestations of airway irritability occurred in both groups. However, laryngospasms and respiratory distress occurred only in the pentothol group, with one of these patients requiring intubation. Patients who have irritable and/or difficult airways may benefit from oral airway insertion that is preceded by propofol induction.