Sticking It to the Niche: CD98 Mediates Critical Adhesive Signals in AML

Andreas Reinisch; Ravindra Majeti

doi:10.1016/j.ccell.2016.10.014

Sticking It to the Niche: CD98 Mediates Critical Adhesive Signals in AML

Cancer Cell. 2016 Nov 14;30(5):662-664. doi: 10.1016/j.ccell.2016.10.014.

Authors

Andreas Reinisch¹, Ravindra Majeti²

Affiliations

¹ Department of Medicine, Division of Hematology, Cancer Institute, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305, USA.
² Department of Medicine, Division of Hematology, Cancer Institute, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 265 Campus Drive, Stanford, CA 94305, USA. Electronic address: [email protected].

PMID: 27846387
DOI: 10.1016/j.ccell.2016.10.014

Abstract

In this issue of Cancer Cell, Bajaj and colleagues report that CD98, a heterodimeric protein highly expressed in acute myeloid leukemia (AML) and largely dispensable for basal hematopoiesis, plays an important role in facilitating leukemia stem cell adhesion to bone marrow vasculature and is a potential therapeutic target in AML.

Publication types

Comment

MeSH terms

Adhesives / metabolism*
Bone Marrow / metabolism
Bone Marrow Cells / metabolism
Hematopoiesis
Humans
Leukemia, Myeloid, Acute / drug therapy*

Substances

Adhesives