Flibanserin and its discontents

Arch Womens Ment Health. 2017 Apr;20(2):243-247. doi: 10.1007/s00737-016-0693-6. Epub 2016 Nov 17.

Abstract

In August 2015, flibanserin (brand name Addyi) was approved by the Food and Drug Administration (FDA) for treatment of acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women. This article summarizes and promotes discussion regarding the numerous controversies that have enclosed flibanserin since the very beginning. This includes questions related to flibanserin's safety and efficacy and the validity of the clinical trials. Also included are philosophical considerations surrounding the diagnosis of hypoactive sexual desire disorder and pharmacological treatment of low libido. Based on the review of literature, authors judge flibanserin to be modestly effective and reasonably safe, and discuss the differences in philosophical perspectives with less definitive answers.

Keywords: Ethics; Female sexuality; Flibanserin; Hypoactive sexual desire disorder; Women’s mental health.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzimidazoles / adverse effects
  • Benzimidazoles / therapeutic use*
  • Female
  • Humans
  • Libido / drug effects*
  • Premenopause*
  • Sexual Dysfunctions, Psychological / drug therapy*
  • Sexual Dysfunctions, Psychological / psychology
  • United States
  • United States Food and Drug Administration

Substances

  • Benzimidazoles
  • flibanserin