A barley flour inhibitor of insect alpha-amylase is a major allergen associated with baker's asthma disease

FEBS Lett. 1989 May 8;248(1-2):119-22. doi: 10.1016/0014-5793(89)80444-2.

Abstract

A barley salt-soluble protein of 14.5 kDa, which inhibits the alpha-amylase from the insect Tenebrio molitor, has been identified as a major IgE-binding component of sera from baker's asthma patients. The N-terminal amino acid sequence of this protein indicates that it is a member of a previously described family of alpha-amylase/trypsin inhibitors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Allergens / adverse effects
  • Allergens / isolation & purification*
  • Amino Acid Sequence
  • Animals
  • Asthma / chemically induced*
  • Chromatography, High Pressure Liquid
  • Edible Grain / analysis*
  • Electrophoresis / methods
  • Flour / adverse effects
  • Flour / analysis*
  • Hordeum / adverse effects
  • Hordeum / analysis*
  • Insecta / enzymology
  • Molecular Sequence Data
  • Occupational Diseases / chemically induced*
  • Trypsin Inhibitors / adverse effects
  • Trypsin Inhibitors / isolation & purification*
  • alpha-Amylases / antagonists & inhibitors*

Substances

  • Allergens
  • Trypsin Inhibitors
  • alpha-Amylases