Abstract
In this article, we review the childhood outcomes of neonates with birth depression and/or hypoxic-ischemic encephalopathy. The outcomes of these children prior to the era of hypothermia for neuroprotection will first be summarized, followed by discussion of results from randomized controlled trials of therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy. The predictors of outcome in childhood following neonatal HIE using clinical and imaging biomarkers following hypothermia therapy will be described.
Copyright © 2016 Elsevier Inc. All rights reserved.
MeSH terms
-
Alanine Transaminase / blood
-
Apgar Score
-
Aspartate Aminotransferases / blood
-
Asphyxia Neonatorum / diagnostic imaging
-
Asphyxia Neonatorum / physiopathology
-
Asphyxia Neonatorum / therapy*
-
Biomarkers / blood
-
Child
-
Creatinine / blood
-
Developmental Disabilities / physiopathology*
-
Developmental Disabilities / prevention & control
-
Disability Evaluation
-
Humans
-
Hypothermia, Induced* / methods
-
Hypoxia-Ischemia, Brain / diagnostic imaging
-
Hypoxia-Ischemia, Brain / physiopathology
-
Hypoxia-Ischemia, Brain / therapy*
-
Infant, Newborn
-
Infant, Newborn, Diseases / diagnostic imaging
-
Infant, Newborn, Diseases / physiopathology
-
Infant, Newborn, Diseases / therapy*
-
Magnetic Resonance Imaging*
-
Neurologic Examination
-
Outcome Assessment, Health Care
-
Randomized Controlled Trials as Topic
-
Severity of Illness Index
Substances
-
Biomarkers
-
Creatinine
-
Aspartate Aminotransferases
-
Alanine Transaminase