Bcl-2 protein family expression pattern determines synergistic pro-apoptotic effects of BH3 mimetics with hemisynthetic cardiac glycoside UNBS1450 in acute myeloid leukemia

Leukemia. 2017 Mar;31(3):755-759. doi: 10.1038/leu.2016.341. Epub 2016 Nov 22.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis / drug effects*
  • Apoptosis Regulatory Proteins / metabolism
  • Cardenolides / pharmacology*
  • Cardiac Glycosides / pharmacology*
  • Cell Line, Tumor
  • Humans
  • Leukemia, Myeloid, Acute / drug therapy*
  • Leukemia, Myeloid, Acute / metabolism
  • Myeloid Cell Leukemia Sequence 1 Protein / metabolism
  • Proto-Oncogene Proteins c-bcl-2 / metabolism*
  • U937 Cells
  • bcl-X Protein / metabolism

Substances

  • Apoptosis Regulatory Proteins
  • BCL2 protein, human
  • Cardenolides
  • Cardiac Glycosides
  • Myeloid Cell Leukemia Sequence 1 Protein
  • Proto-Oncogene Proteins c-bcl-2
  • UNBS 1450
  • bcl-X Protein