The cryptic IRF2BP2-RARA fusion transforms hematopoietic stem/progenitor cells and induces retinoid-sensitive acute promyelocytic leukemia

Leukemia. 2017 Mar;31(3):747-751. doi: 10.1038/leu.2016.338. Epub 2016 Nov 22.

Authors

J V Jovanovic¹, M C Chillón², C Vincent-Fabert³, R Dillon¹, E Voisset¹, N C Gutiérrez², R G Sanz², A A M Lopez², Y G Morgan⁴, J Lok⁴, E Solomon¹, E Duprez³, M G Díaz², D Grimwade¹

Affiliations

¹ King's College London, Faculty of Life Sciences and Medicine, Cancer Genetics Laboratory, Department of Medical and Molecular Genetics, London, UK.
² Hospital Universitario de Salamanca, Instituto de Investigación Biomédica de Salamanca (IBSAL), Centro de Investigación del Cáncer-IBMCC, (USAL-CSIC) Salamanca, Spain.
³ Centre de Recherche en Cancérologie de Marseille U1068 INSERM, UMR 7258 CNRS, Aix-Marseille Université, Marseille, France.
⁴ Molecular Oncology Section, Cancer Genetics, Viapath, Guy's Hospital, London, UK.

PMID: 27872498
DOI: 10.1038/leu.2016.338

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Carrier Proteins / metabolism*
Chromosomes, Human, Pair 15 / metabolism
Chromosomes, Human, Pair 17 / metabolism
DNA-Binding Proteins
Hematopoietic Stem Cells / metabolism*
Humans
Leukemia, Promyelocytic, Acute / metabolism*
Male
Nuclear Proteins / metabolism*
Oncogene Proteins, Fusion / metabolism*
Retinoic Acid Receptor alpha / metabolism*
Retinoids / metabolism*
Stem Cells / metabolism*
Transcription Factors
Translocation, Genetic / physiology

Substances

Carrier Proteins
DNA-Binding Proteins
IRF2BP2 protein, human
Nuclear Proteins
Oncogene Proteins, Fusion
RARA protein, human
Retinoic Acid Receptor alpha
Retinoids
Transcription Factors