Abstract
A three dimensional supramolecular hydrogel consisting of prodrug-modified graphene oxide and α-cyclodextrin was developed. This hydrogel with a well-ordered interior microstructure integrated hydrophobic and hydrophilic anticancer drugs into a single multifunctional platform, and underwent a gel-sol transition leading to cascade release of two drugs in an on-demand fashion upon NIR light irradiation.
MeSH terms
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Animals
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Antineoplastic Agents / administration & dosage*
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Antineoplastic Agents / pharmacokinetics
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Camptothecin / administration & dosage*
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Camptothecin / pharmacokinetics
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Delayed-Action Preparations / chemistry*
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Drug Delivery Systems
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Fluorouracil / administration & dosage*
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Fluorouracil / pharmacokinetics
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Graphite / chemistry*
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Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry*
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Infrared Rays
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Mice
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Oxides / chemistry
Substances
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Antineoplastic Agents
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Delayed-Action Preparations
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Oxides
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Hydrogel, Polyethylene Glycol Dimethacrylate
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Graphite
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Fluorouracil
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Camptothecin