Flexible synthesis of cationic peptide-porphyrin derivatives for light-triggered drug delivery and photodynamic therapy

R Dondi; E Yaghini; K M Tewari; L Wang; F Giuntini; M Loizidou; A J MacRobert; I M Eggleston

doi:10.1039/c6ob02135b

Flexible synthesis of cationic peptide-porphyrin derivatives for light-triggered drug delivery and photodynamic therapy

Org Biomol Chem. 2016 Dec 7;14(48):11488-11501. doi: 10.1039/c6ob02135b.

Authors

R Dondi¹, E Yaghini², K M Tewari¹, L Wang³, F Giuntini¹, M Loizidou², A J MacRobert², I M Eggleston¹

Affiliations

¹ Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK. [email protected].
² UCL Division of Surgery and Interventional Science, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK.
³ Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK. [email protected] and School of Pharmaceutical Sciences, Shandong University, Jinan, China.

Abstract

Efficient syntheses of cell-penetrating peptide-porphyrin conjugates are described using a variety of bioconjugation chemistries. This provides a flexible means to convert essentially hydrophobic tetrapyrolle photosensitisers into amphiphilic derivatives which are well-suited for use in light-triggered drug delivery by photochemical internalisation (PCI) and targeted photodynamic therapy (PDT).

MeSH terms

Antimicrobial Cationic Peptides / chemical synthesis*
Antimicrobial Cationic Peptides / chemistry
Drug Delivery Systems*
Light*
Molecular Structure
Phenothiazines / chemical synthesis*
Phenothiazines / chemistry
Photochemotherapy*
Porphyrins / chemical synthesis*
Porphyrins / chemistry

Substances

Antimicrobial Cationic Peptides
Phenothiazines
Porphyrins

Abstract

MeSH terms

Substances

Grants and funding