Meticillin-resistant Staphylococcus aureus (MRSA) acquisition risk in an endemic neonatal intensive care unit with an active surveillance culture and decolonization programme

R Pierce; J Lessler; V O Popoola; A M Milstone

doi:10.1016/j.jhin.2016.10.022

Meticillin-resistant Staphylococcus aureus (MRSA) acquisition risk in an endemic neonatal intensive care unit with an active surveillance culture and decolonization programme

J Hosp Infect. 2017 Jan;95(1):91-97. doi: 10.1016/j.jhin.2016.10.022. Epub 2016 Nov 4.

Authors

R Pierce¹, J Lessler¹, V O Popoola², A M Milstone³

Affiliations

¹ Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
² Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Pediatrics, Division of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MA, USA.
³ Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Pediatrics, Division of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MA, USA; Department of Hospital Epidemiology and Infection Control, Johns Hopkins Hospital, Baltimore, MA, USA. Electronic address: [email protected].

Abstract

Background: Meticillin-resistant Staphylococcus aureus (MRSA) is a leading cause of healthcare-associated infection in the neonatal intensive care unit (NICU). Decolonization may eliminate bacterial reservoirs that drive MRSA transmission.

Aim: To measure the association between colonization pressure from decolonized and non-decolonized neonates and MRSA acquisition to inform use of this strategy for control of endemic MRSA.

Methods: An eight-year retrospective cohort study was conducted in a level-4 NICU that used active surveillance cultures and decolonization for MRSA control. Weekly colonization pressure exposures were defined as the number of patient-days of concurrent admission with treated (decolonized) and untreated (non-decolonized) MRSA carriers in the preceding seven days. Poisson regression was used to estimate risk of incident MRSA colonization associated with colonization pressure exposures. The population-attributable fraction was calculated to assess the proportion of overall unit MRSA incidence attributable to treated or untreated patients in this setting.

Findings: Every person-day increase in exposure to an untreated MRSA carrier was associated with a 6% increase in MRSA acquisition risk [relative risk (RR): 1.06; 95% confidence interval (CI): 1.01-1.11]. Risk of acquisition was not influenced by exposure to treated, isolated MRSA carriers (RR: 1.01; 95% CI: 0.98-1.04). In the context of this MRSA control programme, 22% (95% CI: 4.0-37) of MRSA acquisition could be attributed to exposures to untreated MRSA carriers.

Conclusion: Untreated MRSA carriers were an important reservoir for transmission. Decolonized patients on contact isolation posed no detectable transmission threat, supporting the hypothesis that decolonization may reduce patient-to-patient transmission. Non-patient reservoirs may contribute to unit MRSA acquisition and require further investigation.

Keywords: Decolonization; Intensive care unit; Meticillin-resistant Staphylococcus aureus; Staphylococcal infections; Transmission.

Publication types

Observational Study

MeSH terms

Carrier State / epidemiology*
Carrier State / microbiology
Cross Infection / epidemiology*
Cross Infection / microbiology
Cross Infection / transmission
Disease Reservoirs
Endemic Diseases
Epidemiological Monitoring
Female
Humans
Incidence
Infant
Infant, Newborn
Intensive Care Units, Neonatal*
Male
Methicillin-Resistant Staphylococcus aureus / isolation & purification*
Retrospective Studies
Risk Assessment
Staphylococcal Infections / epidemiology*
Staphylococcal Infections / microbiology
Staphylococcal Infections / transmission

Abstract

Publication types

MeSH terms

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