Allele and genotype frequencies of polymorphisms in cytokine genes in ethnic Russian individuals from Moscow, Russia

Alexandra Shadrina; Elena Voronina; Igor Zolotukhin; Maxim Filipenko

doi:10.1016/j.humimm.2016.11.007

Allele and genotype frequencies of polymorphisms in cytokine genes in ethnic Russian individuals from Moscow, Russia

Hum Immunol. 2017 Feb;78(2):190-191. doi: 10.1016/j.humimm.2016.11.007. Epub 2016 Nov 23.

Authors

Alexandra Shadrina¹, Elena Voronina², Igor Zolotukhin³, Maxim Filipenko²

Affiliations

¹ Institute of Chemical Biology and Fundamental Medicine, Lavrentjeva Street, 8, Novosibirsk 630090, Russia. Electronic address: [email protected].
² Institute of Chemical Biology and Fundamental Medicine, Lavrentjeva Street, 8, Novosibirsk 630090, Russia.
³ Pirogov Russian National Research Medical University, Ostrovitianova Street, 1, Moscow 117997, Russia.

PMID: 27888067
DOI: 10.1016/j.humimm.2016.11.007

Abstract

Two hundred and twenty eight ethnic Russian individuals from Moscow, Russia, were genotyped at 14 single nucleotide polymorphisms CCL2 A-2578G; VEGFA C-2578A, G-634C, and C+936T; TNF G+419A and G-308A; IL1A G-889A; IL1RN T+1018C; IL6G-174C and G-572C; IFNG T+874A; IL1B C-511T; IL10 A+1082G; TGFB1 C-509T. Genotypes were determined using real-time polymerase chain reaction with TaqMan probes and polymerase chain reaction followed by melting analysis of dual-labeled probe. Genotype distribution was in accordance with Hardy-Weinberg equilibrium for all studied polymorphisms. Genotype data are available in the Allele Frequencies Net Database under identifier AFND 3367 and the population name "Russia Moscow Cytokine".

Keywords: Allele; Cytokine; Ethnic Russians; Polymorphism; SNP.

MeSH terms

Adult
Aged
Aged, 80 and over
Cytokines / genetics*
Databases, Genetic
Ethnicity
Female
Gene Frequency
Genetics, Population
Genotype*
Humans
Male
Middle Aged
Moscow
Polymorphism, Genetic*
Russia
Young Adult

Substances

Cytokines