Biofilm and Osteitis in Refractory Chronic Rhinosinusitis

Yi Chen Zhao; Peter-John Wormald

doi:10.1016/j.otc.2016.08.005

Biofilm and Osteitis in Refractory Chronic Rhinosinusitis

Otolaryngol Clin North Am. 2017 Feb;50(1):49-60. doi: 10.1016/j.otc.2016.08.005.

Authors

Yi Chen Zhao¹, Peter-John Wormald²

Affiliations

¹ Department of Surgery - Otolaryngology Head & Neck Surgery, The University of Adelaide, Adelaide, Queen Elizabeth Hospital 28 Woodville Rd, Woodville South, South Australia 5011, Australia.
² Department of Surgery - Otolaryngology Head & Neck Surgery, The University of Adelaide, Adelaide, Queen Elizabeth Hospital 28 Woodville Rd, Woodville South, South Australia 5011, Australia. Electronic address: [email protected].

PMID: 27888915
DOI: 10.1016/j.otc.2016.08.005

Abstract

Our understanding of chronic rhinosinusitis (CRS) show biofilm and osteitis play a role in the disease's pathogenesis and refractory. Studies point to its role in pathogenesis and poor prognosis. Outside the research laboratory, biofilm detection remains difficult and specific treatment remains elusive. It is believed that osteitis is a nidus of inflammation and occurs more commonly in patients with refractory CRS. However, osteitis may be exacerbated by surgery and a marker of refractory disease, not a causative agent. Surgery remains the mainstay treatment for biofilm and osteitis with mechanical disruption and removal of disease load providing the most effective treatment.

Keywords: Biofilm; Endoscopic surgery; Osteitis; Refractory rhinosinusitis.

Publication types

Review

MeSH terms

Biofilms* / drug effects
Biofilms* / growth & development
Chronic Disease
Disease Management
Humans
Nasal Bone / pathology*
Osteitis* / immunology
Osteitis* / physiopathology
Osteitis* / surgery
Prognosis
Rhinitis* / diagnosis
Rhinitis* / physiopathology
Sinusitis* / diagnosis
Sinusitis* / physiopathology
Sinusitis* / therapy