An α-helical peptidomimetic scaffold for dynamic combinatorial library formation

Nathalie Busschaert; Sam Thompson; Andrew D Hamilton

doi:10.1039/c6cc07787k

An α-helical peptidomimetic scaffold for dynamic combinatorial library formation

Chem Commun (Camb). 2016 Dec 22;53(2):313-316. doi: 10.1039/c6cc07787k.

Authors

Nathalie Busschaert¹, Sam Thompson², Andrew D Hamilton¹

Affiliations

¹ Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003, USA. [email protected] and Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK. [email protected].
² Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, UK. [email protected] and Chemistry, University of Southampton, Southampton, SO17 1BJ, UK. [email protected].

PMID: 27892554
DOI: 10.1039/c6cc07787k

Abstract

A novel oligobenzamide-based α-helix mimetic was designed and synthesised with either imine or hydrazone functionalities that serve both to pre-organise the side-chain vectors to mimic the i, i + 4 and i + 7 residues of an α-helix, and to allow for the facile creation of dynamic libraries.

MeSH terms

Combinatorial Chemistry Techniques*
Models, Molecular
Peptidomimetics / chemical synthesis*
Peptidomimetics / chemistry*
Protein Conformation, alpha-Helical

Substances

Peptidomimetics