Converting Red Blood Cells to Efficient Microreactors for Blood Detoxification

Can Xu; Xiangyu Yang; Xiao Fu; Rui Tian; Orit Jacobson; Zhantong Wang; Nan Lu; Yijing Liu; Wenpei Fan; Fuwu Zhang; Gang Niu; Shuo Hu; Iqbal Unnisa Ali; Xiaoyuan Chen

doi:10.1002/adma.201603673

Converting Red Blood Cells to Efficient Microreactors for Blood Detoxification

Adv Mater. 2017 Feb;29(6):10.1002/adma.201603673. doi: 10.1002/adma.201603673. Epub 2016 Nov 28.

Authors

Can Xu^{1

2}, Xiangyu Yang², Xiao Fu², Rui Tian², Orit Jacobson², Zhantong Wang², Nan Lu², Yijing Liu², Wenpei Fan², Fuwu Zhang², Gang Niu², Shuo Hu¹, Iqbal Unnisa Ali², Xiaoyuan Chen²

Affiliations

¹ Department of PET Center, Xiangya Hospital, Central South University, Changsha, 410008, China.
² Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.

Abstract

A simple method to convert red blood cells (RBCs) into efficient microreactors is reported. Triton X-100 is employed at finely tuned concentrations to render RBCs highly permeable to substrates, while low concentrations of glutaraldehyde are used to stabilize cells. The ability for blood detoxification of these microreactors is demonstrated.

Keywords: Triton X-100 (TX); blood detoxification; glutaraldehyde (GA); microreactors; red blood cells (RBC).

Converting Red Blood Cells to Efficient Microreactors for Blood Detoxification

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Abstract

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