The effect of oxytocin on basal and pethidine-induced delayed gastric emptying

Br J Clin Pharmacol. 1989 Sep;28(3):329-32. doi: 10.1111/j.1365-2125.1989.tb05434.x.

Abstract

1. Continuous infusion of oxytocin (0.33 u min-1) accelerated gastric emptying of semisolid TC-99m labelled Chelex-100 resin/oatmeal in 10 healthy volunteers under basal conditions. 2. Administration of oxytocin did not change the pattern of gastric emptying delayed by pethidine. 3. The emptying pattern of semisolid has confirmed the existence of a lag phase.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Double-Blind Method
  • Female
  • Gastric Emptying / drug effects*
  • Humans
  • Male
  • Meperidine / pharmacology*
  • Oxytocin / pharmacology*

Substances

  • Oxytocin
  • Meperidine