Restoration of the Hypothalamic-pituitary-adrenal Response to Hypoglycemia in Type 2 Diabetes by Avoiding Chronic Hypoglycemia

Shin-Ichi Tsuda; Kazunori Konishi; Toshiki Otoda; Takako Nagai; Ai Takeda-Watanabe; Megumi Kanasaki; Munehiro Kitada; Atsushi Nakagawa; Makoto Nishizawa; Keizo Kanasaki; Daisuke Koya

doi:10.2169/internalmedicine.55.7001

Restoration of the Hypothalamic-pituitary-adrenal Response to Hypoglycemia in Type 2 Diabetes by Avoiding Chronic Hypoglycemia

Intern Med. 2016;55(23):3471-3473. doi: 10.2169/internalmedicine.55.7001. Epub 2016 Dec 1.

Authors

Shin-Ichi Tsuda¹, Kazunori Konishi, Toshiki Otoda, Takako Nagai, Ai Takeda-Watanabe, Megumi Kanasaki, Munehiro Kitada, Atsushi Nakagawa, Makoto Nishizawa, Keizo Kanasaki, Daisuke Koya

Affiliation

¹ Department of Diabetology & Endocrinology, Kanazawa Medical University, Japan.

Abstract

An impaired ability to sense and respond to drug-induced hypoglycemia is a common and serious complication in diabetic patients. The hypothalamic-pituitary-adrenal (HPA) axis activity plays a critical role in the counterregulatory response to hypoglycemia. We herein report a case that experienced restoration of a blunted HPA axis by avoiding hypoglycemia with the use of the DPP-4 inhibitor sitagliptin.

Publication types

Case Reports

MeSH terms

Aged
Diabetes Mellitus, Type 2 / drug therapy*
Diabetes Mellitus, Type 2 / physiopathology
Dipeptidyl-Peptidase IV Inhibitors / therapeutic use*
Female
Humans
Hypoglycemia / physiopathology
Hypoglycemic Agents / therapeutic use*
Hypothalamo-Hypophyseal System / drug effects*
Hypothalamo-Hypophyseal System / physiopathology
Pituitary-Adrenal System / drug effects*
Pituitary-Adrenal System / physiopathology
Sitagliptin Phosphate / therapeutic use*

Substances

Dipeptidyl-Peptidase IV Inhibitors
Hypoglycemic Agents
Sitagliptin Phosphate