Effects of Anti-CD206 Antibodies on Macrophage Functions in Male CBF1 Mice with Lipidemia

A P Lykov; T A Korolenko; L V Sakhno; O V Poveshchenko; N A Bondarenko; M A Surovtseva; N V Goncharova

doi:10.1007/s10517-016-3584-y

Effects of Anti-CD206 Antibodies on Macrophage Functions in Male CBF1 Mice with Lipidemia

Bull Exp Biol Med. 2016 Dec;162(2):237-239. doi: 10.1007/s10517-016-3584-y. Epub 2016 Dec 1.

Authors

A P Lykov¹, T A Korolenko², L V Sakhno³, O V Poveshchenko⁴, N A Bondarenko⁴, M A Surovtseva⁴, N V Goncharova²

Affiliations

¹ Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia. [email protected].
² Research Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia.
³ Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
⁴ Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.

PMID: 27909959
DOI: 10.1007/s10517-016-3584-y

Abstract

The effects of anti-CD208 antibodies (mannose receptor) on functional characteristics of peritoneal macrophages were studied in intact mice and mice with lipidemia induced by poloxamer-407. Lipidemia was associated with suppression of phagocytosis and increase in spontaneous proliferative potential and NO production by macrophages. Anti-CD206 antibodies suppressed NO production by macrophages in mice with lipidemia.

Keywords: P-407; lipidemia; macrophages; phagocytosis; reactive oxygen species.

MeSH terms

Animals
Antibodies / pharmacology*
Cell Proliferation / drug effects
Erythrocytes / immunology
Gene Expression
Hyperlipidemias / chemically induced
Hyperlipidemias / genetics
Hyperlipidemias / immunology*
Hyperlipidemias / pathology
Lectins, C-Type / antagonists & inhibitors*
Lectins, C-Type / genetics
Lectins, C-Type / immunology
Lipopolysaccharides / pharmacology
Macrophages, Peritoneal / drug effects*
Macrophages, Peritoneal / immunology
Macrophages, Peritoneal / pathology
Male
Mannose Receptor
Mannose-Binding Lectins / antagonists & inhibitors*
Mannose-Binding Lectins / genetics
Mannose-Binding Lectins / immunology
Mice
Nitric Oxide / biosynthesis
Phagocytosis / drug effects*
Poloxamer
Primary Cell Culture
Reactive Oxygen Species / immunology
Reactive Oxygen Species / metabolism
Receptors, Cell Surface / antagonists & inhibitors*
Receptors, Cell Surface / genetics
Receptors, Cell Surface / immunology
Sheep

Substances

Antibodies
Lectins, C-Type
Lipopolysaccharides
Mannose Receptor
Mannose-Binding Lectins
Reactive Oxygen Species
Receptors, Cell Surface
Poloxamer
Nitric Oxide