Primary cilia are sensory organelles that play a role as signalling hubs. Disruption of primary cilia structure and function is increasingly recognised in a range of cancers, with a growing body of evidence suggesting that ciliary disruption contributes to tumourigenesis. This review considers the role of primary cilia in the pathogenesis of endocrine-related cancers.
Keywords: Von Hippel–Lindau; breast cancers; cilia; endocrine cancer; ovarian cancer; prostate cancer.
© 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society.