Parental origin of chromosomal nondisjunction in a 49,XXXXY male using recombinant-DNA techniques

Clin Genet. 1989 Sep;36(3):152-5. doi: 10.1111/j.1399-0004.1989.tb03181.x.

Authors

M Villamar¹, J Benitez, E Fernández, C Ayuso, C Ramos

Affiliation

¹ Departamento de Genética, Fundación Jiménez Diaz, Madrid, Spain.

PMID: 2791329
DOI: 10.1111/j.1399-0004.1989.tb03181.x

Abstract

We have analyzed the origin, in a patient with 49,XXXXY, of the four X-chromosomes by means of recombinant DNA techniques. We found a maternal origin of the four X-chromosomes due to non-disjunctions in the first and second meiotic divisions.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Child, Preschool
DNA Probes
DNA, Recombinant*
Facial Bones / abnormalities
Genetic Linkage
Humans
Male
Meiosis
Mothers*
Nondisjunction, Genetic*
Polyploidy
Psychomotor Disorders / genetics
Sex Chromosome Aberrations / genetics*
Skull / abnormalities
X Chromosome*

Substances

DNA Probes
DNA, Recombinant