Anti-Xa monitoring of low-molecular-weight heparin in adult patients with cancer

Hematology Am Soc Hematol Educ Program. 2016 Dec 2;2016(1):206-207. doi: 10.1182/asheducation-2016.1.206.

Abstract

A 68-year-old man developed a right femoral vein deep vein thrombosis and bilateral pulmonary embolism while receiving chemotherapy for stage IV prostate cancer. His creatinine at diagnosis is 1.4 mg/dL, with an estimated clearance of 63 mL/min. In patients with cancer, should low-molecular-weight heparin treatment be dosed according to weight, or adjusted using anti-Xa levels?

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Aged
  • Factor Xa Inhibitors* / administration & dosage
  • Factor Xa Inhibitors* / pharmacokinetics
  • Heparin, Low-Molecular-Weight* / administration & dosage
  • Heparin, Low-Molecular-Weight* / pharmacokinetics
  • Humans
  • Male
  • Prostatic Neoplasms / blood
  • Prostatic Neoplasms / drug therapy*
  • Pulmonary Embolism* / blood
  • Pulmonary Embolism* / drug therapy
  • Pulmonary Embolism* / etiology
  • Venous Thrombosis* / blood
  • Venous Thrombosis* / drug therapy
  • Venous Thrombosis* / etiology

Substances

  • Factor Xa Inhibitors
  • Heparin, Low-Molecular-Weight