Differential Cell Count and CRP Level in Blood as Predictors for Middle East Respiratory Syndrome Coronavirus Infection in Acute Febrile Patients during Nosocomial Outbreak

J Korean Med Sci. 2017 Jan;32(1):151-154. doi: 10.3346/jkms.2017.32.1.151.

Abstract

A case-control study was performed to identify clinical predictors for Middle East respiratory syndrome coronavirus (MERS-CoV) infection among patients with acute febrile illness during the nosocomial outbreak. Patients with MERS-CoV were more likely to have monocytosis with normal white blood cell (WBC) count and lower C-reactive protein (CRP) level. Simple laboratory data such as complete blood counts (CBC) with differential count could be a useful marker for the prediction of MERS and triage at the initial presentation of acute febrile patients in outbreak setting.

Keywords: Coronavirus; Middle East Respiratory Syndrome; Monocytosis; Predictors.

MeSH terms

  • Adult
  • Biomarkers / analysis
  • Biomarkers / blood
  • C-Reactive Protein / analysis*
  • Case-Control Studies
  • Coronavirus Infections / diagnosis*
  • Coronavirus Infections / epidemiology
  • Disease Outbreaks
  • Female
  • Humans
  • Leukocyte Count
  • Leukocytes / cytology
  • Leukocytes / metabolism
  • Leukocytosis / etiology
  • Male
  • Middle Aged
  • Odds Ratio
  • Predictive Value of Tests

Substances

  • Biomarkers
  • C-Reactive Protein