Expression of Glut-1 and HK-II in Pancreatic Cancer and Their Impact on Prognosis and FDG Accumulation

Hai-Jing Yang; Wei-Jia Xu; Yi-Hui Guan; Hui-Wei Zhang; Wei-Qun Ding; Lan Rong; Zhi-Bing Qiu; Liang Zhong

doi:10.1016/j.tranon.2016.08.004

Expression of Glut-1 and HK-II in Pancreatic Cancer and Their Impact on Prognosis and FDG Accumulation

Transl Oncol. 2016 Dec;9(6):583-591. doi: 10.1016/j.tranon.2016.08.004.

Authors

Hai-Jing Yang¹, Wei-Jia Xu², Yi-Hui Guan³, Hui-Wei Zhang³, Wei-Qun Ding⁴, Lan Rong⁴, Zhi-Bing Qiu⁴, Liang Zhong⁵

Affiliations

¹ Department of Gastroenterology, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai 200040, China. Electronic address: [email protected].
² Department of Gastroenterology, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai 200040, China. Electronic address: [email protected].
³ PET Center of Huashan Hospital, Fudan University, 518 Wuzhong East Road, Shanghai 200235, China.
⁴ Department of Gastroenterology, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai 200040, China.
⁵ Department of Gastroenterology, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai 200040, China. Electronic address: [email protected].

Abstract

Objective: The purpose of this article is to analyze the expression of Glut-1 and HK-II, the association between their expression and ¹⁸F-FDG accumulation in pancreatic cancer.

Methods: Fifty patients with histologically proven pancreatic cancer were included in this preliminary study, all of whom received ¹⁸F-FDG PET/CT performance before surgery. Immunohistochemical staining of tumor tissue and adjacent normal tissue was performed for Glut-1 and HK-II. By combining proportions and intensity of immunochemical staining, we obtained the modified immunohistological scores for Glut-1 and HK-II respectively. The relationship between expression of Glut-1, HK-II and series of parameters was analyzed, i.e. clinicopathological characteristics, prognosis of patients and SUV_max of PET-CT.

Results: Compared with normal tissue, the Glut-1 and HK-II expression in pancreatic cancer tissue was significantly increased (P<.001). There was no correlation between expression of Glut-1, HK-II and age, gender, tumor size, tumor location, tumor histological type, tumor differentiation, the nerve infiltration, vascular invasion, local infiltration, lymph node metastasis or tumor staging in pancreatic cancer (P>.05). During the follow-up period, the survival curves of low Glut-1 group and high Glut-1 group were statistically different (P=.049). Multivariate analysis (Cox regression) revealed that Glut-1 expression was not associated with mortality (P>.05). No statistical difference was found in the survival curves of negative HK-II group and positive HK-II group (P=.545). There was no correlation between ¹⁸F-FDG uptake and expression of Glut-1 and HK-II(P>.05).

Conclusion: The Glut-1 and HK-II expression in pancreatic cancer tissue was significantly increased. There was no correlation between expression of Glut-1, HK-II and clinicopathological characteristics, prognosis and ¹⁸F-FDG uptake.