Co-delivery of all-trans-retinoic acid enhances the anti-metastasis effect of albumin-bound paclitaxel nanoparticles

Hai Huang; Hongdong Shi; Jing Liu; Yuanzeng Min; Yucai Wang; Andrew Z Wang; Jun Wang; Yangzhong Liu

doi:10.1039/c6cc08146k

Co-delivery of all-trans-retinoic acid enhances the anti-metastasis effect of albumin-bound paclitaxel nanoparticles

Chem Commun (Camb). 2016 Dec 20;53(1):212-215. doi: 10.1039/c6cc08146k.

Authors

Hai Huang¹, Hongdong Shi¹, Jing Liu², Yuanzeng Min³, Yucai Wang², Andrew Z Wang³, Jun Wang², Yangzhong Liu¹

Affiliations

¹ CAS Key Laboratory of Soft Matter Chemistry, CAS High Magnetic Field Laboratory, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China. [email protected].
² School of Life Sciences, University of Science and Technology of China, China.
³ Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

PMID: 27918025
DOI: 10.1039/c6cc08146k

Abstract

Co-delivery of all-trans-retinoic acid and paclitaxel using albumin-bound nanoparticles demonstrated a significantly improved anti-metastatic effect to breast cancer both in vitro and in vivo. Notably, the co-delivery nanoparticles exhibited more pronounced therapeutic effects than the combination of two free drugs or two HSA loaded single drugs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Albumin-Bound Paclitaxel / chemistry*
Albumin-Bound Paclitaxel / pharmacology*
Animals
Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology*
Breast Neoplasms / pathology
Cell Line, Tumor
Drug Carriers / chemistry*
Humans
Mice
Models, Molecular
Nanoparticles / chemistry*
Neoplasm Metastasis
Protein Conformation
Tretinoin / chemistry*

Substances

Albumin-Bound Paclitaxel
Antineoplastic Agents
Drug Carriers
Tretinoin