Abstract
On the basis of a similarity between certain neurological symptoms of AIDS and Alzheimer's disease, the authors studied the effects of tetrahydroaminoacridine (THA) in 9 patients with HIV infection. After 2 months of treatment, the preliminary results showed a significant increase in CD4 lymphocyte count as well as a decrease in p24 antigen level in 8 patients, of whom 4 became negative for the p24 antigen.
MeSH terms
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Acquired Immunodeficiency Syndrome / complications
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Acquired Immunodeficiency Syndrome / drug therapy*
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Adult
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Alanine Transaminase / blood
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Aminoacridines / therapeutic use*
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Aspartate Aminotransferases / blood
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CD4 Antigens / analysis
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Female
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HIV Antigens / analysis
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Humans
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Leukocyte Count
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Male
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Middle Aged
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Opportunistic Infections / prevention & control
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Tacrine / adverse effects
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Tacrine / therapeutic use*
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Time Factors
Substances
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Aminoacridines
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CD4 Antigens
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HIV Antigens
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Tacrine
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Aspartate Aminotransferases
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Alanine Transaminase