Abstract
An efficient asymmetric synthesis of dipyridyl TRPV3 antagonist 1 is reported. The four-step route involves two C-C bond-forming steps, a highly diastereoselective alkene hydration, and asymmetric ketone hydrosilylation in 97% ee.
MeSH terms
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Carbon-13 Magnetic Resonance Spectroscopy
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Humans
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Proton Magnetic Resonance Spectroscopy
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Pyridines / chemistry
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Spectrometry, Mass, Electrospray Ionization
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Stereoisomerism
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TRPV Cation Channels / antagonists & inhibitors*
Substances
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Pyridines
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TRPV Cation Channels
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TRPV3 protein, human