Evidence for the existence of prejunctional receptor sites for dopamine in the mouse vas deferens

J Auton Nerv Syst. 1989 Aug;27(3):221-8. doi: 10.1016/0165-1838(89)90115-x.

Abstract

The present work is focused on the effects of newly developed dopaminergic agonists and antagonists on the field-stimulated vas deferens. Both LY 171555 and SK&F 38393, relatively selective DA2 and DA1 receptor agonists, respectively, produced concentration-dependent inhibition of the field stimulation-evoked contractions in the mouse vas deferens; both compounds did not modify the baseline tone nor the contractile responses to exogenous noradrenaline. Control LY 171555 and SK&F 38393 concentration-response curves, were shifted rightward in a parallel manner in the presence of sulpiride (relatively specific DA2 antagonist) and SCH 23390 (relatively specific DA1 antagonist), respectively. Control concentration-response curves for dopaminergic agonists were not modified in the presence of specific blockers for H1 and H2 histamine receptors, serotonin receptors and alpha 2-adrenoceptors. These preliminary findings are suggestive of the existence of two dopaminergic receptor types both presumably located prejunctionally.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / pharmacology
  • Adrenergic Fibers / drug effects
  • Adrenergic Fibers / metabolism*
  • Adrenergic Fibers / physiology
  • Animals
  • Clonidine / pharmacology
  • Electric Stimulation
  • Ergolines / pharmacology
  • In Vitro Techniques
  • Male
  • Mice
  • Muscle Contraction / drug effects
  • Muscle, Smooth / innervation*
  • Muscle, Smooth / physiology
  • Quinpirole
  • Receptors, Dopamine / drug effects
  • Receptors, Dopamine / physiology*
  • Vas Deferens / innervation*
  • Vas Deferens / physiology

Substances

  • Ergolines
  • Receptors, Dopamine
  • Quinpirole
  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
  • Clonidine