The familial study of three patients from the Osona region (Barcelona) with early onset (fourth decade) of articular chondrocalcinosis (CCA) disclosed the occurrence of CCA in other members of the three families. The clinical and radiological features were heterogeneous, with polyarticular forms with marked clinical expression in one family, oligoarticular forms with few symptoms in another, and both types in the third family. These first reports of familial CCA in Catalonia can be added to those found in other parts of Spain, and they support the idea that familial cases of CCA are not exceptional if adequately investigated.