A simply triggered peptide-based hydrogel as an injectable nanocarrier of tanshinone IIA and tanshinones

Yajun Yin; Can Wu; Junling Wang; Fengjuan Song; Wanqing Yue; Wenying Zhong

doi:10.1039/c6cc08502d

A simply triggered peptide-based hydrogel as an injectable nanocarrier of tanshinone IIA and tanshinones

Chem Commun (Camb). 2017 Jan 3;53(3):529-532. doi: 10.1039/c6cc08502d.

Authors

Yajun Yin¹, Can Wu¹, Junling Wang¹, Fengjuan Song¹, Wanqing Yue², Wenying Zhong²

Affiliations

¹ Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, China.
² Department of Analytical Chemistry, China Pharmaceutical University, Nanjing, China and Key Laboratory of Biomedical Functional Materials, China Pharmaceutical University, Nanjing 210009, P. R. China. [email protected] [email protected].

PMID: 27966687
DOI: 10.1039/c6cc08502d

Abstract

An easily self-assembled and gelated octa-peptide FHFDFHFD was chosen as a novel drug delivery system (DDS) for both tanshinone IIA and total tanshinone extract. The DDS showed increased loading capacity, sustained drug release and better anticancer capability. Our research proved that a hydrogel DDS of other traditional Chinese medicines is possible.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

A549 Cells
Abietanes / administration & dosage*
Abietanes / pharmacology
Amino Acid Sequence
Antineoplastic Agents, Phytogenic / administration & dosage*
Antineoplastic Agents, Phytogenic / pharmacology
Cell Survival / drug effects
Delayed-Action Preparations / chemistry*
Humans
Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry*
Injections
Models, Molecular
Nanostructures / chemistry
Nanostructures / ultrastructure
Neoplasms / drug therapy
Oligopeptides / chemistry*

Substances

Abietanes
Antineoplastic Agents, Phytogenic
Delayed-Action Preparations
Oligopeptides
tanshinone
Hydrogel, Polyethylene Glycol Dimethacrylate