Biochemical Changes in the Niche Following Tumor Cell Invasion

J Cell Biochem. 2017 Aug;118(8):1956-1964. doi: 10.1002/jcb.25843. Epub 2017 Apr 18.

Abstract

Metastatic cancer is the leading cause of all cancer related deaths. Prostate cancer (PCa) metastasizes preferentially to the bone marrow, specifically within the endosteal niche. Endosteal cells secrete homing molecules that may recruit PCa cells to the bone marrow. Once there, the biochemical signature of this niche regulates PCa fate including cellular dormancy or cell cycle arrest, reactivation and resistance to chemotherapeutics. Growth factors, interleukins, adhesion molecules, as well as extra-cellular matrix proteins can collectively change the phenotype of PCa cells. Understanding the biochemical signature of endosteal niche parasitism by PCa is imperative for the establishment of new and innovative therapeutic strategies. This review seeks to summarize these important niche signatures and the potential therapeutic approaches to target metastatic PCa within the bone marrow hematopoietic stem cell (HSC) niche. J. Cell. Biochem. 118: 1956-1964, 2017. © 2016 Wiley Periodicals, Inc.

Keywords: DISSEMINATED TUMOR CELL (DTC); METASTASIS; NICHE; OSTEOBLAST; PROSTATE CANCER (PCa).

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, N.I.H., Extramural

MeSH terms

  • Bone Marrow / immunology
  • Bone Marrow / pathology*
  • Bone Marrow Neoplasms / genetics*
  • Bone Marrow Neoplasms / immunology
  • Bone Marrow Neoplasms / secondary
  • Cell Adhesion Molecules / genetics
  • Cell Adhesion Molecules / immunology
  • Cell Movement
  • Extracellular Matrix Proteins / genetics
  • Extracellular Matrix Proteins / immunology
  • Gene Expression Regulation, Neoplastic*
  • Hematopoietic Stem Cells / immunology
  • Hematopoietic Stem Cells / pathology*
  • Humans
  • Intercellular Signaling Peptides and Proteins / genetics
  • Intercellular Signaling Peptides and Proteins / immunology
  • Interleukins / genetics
  • Interleukins / immunology
  • Male
  • Neoplastic Cells, Circulating / immunology
  • Neoplastic Cells, Circulating / pathology
  • Periosteum / immunology
  • Periosteum / pathology*
  • Prostatic Neoplasms / genetics*
  • Prostatic Neoplasms / immunology
  • Prostatic Neoplasms / pathology
  • Signal Transduction
  • Stem Cell Niche / genetics*
  • Stem Cell Niche / immunology

Substances

  • Cell Adhesion Molecules
  • Extracellular Matrix Proteins
  • Intercellular Signaling Peptides and Proteins
  • Interleukins